OECD Guidelines for the Testing of Chemicals

Regulatory Toxicology Testing

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OECD Guidelines for the Testing of Chemicals


The OECD Guidelines for the Testing of Chemicals is an internationally agreed upon collection of testing methods used by government, industry and independent laboratories to identify and characterize potential chemical hazards. These approved assays are testing tools used primarily in regulatory safety testing as well as, subsequent chemical product notifications, chemical registrations and in chemical evaluations. They can also be used for the selection and ranking during the development of new products and chemical agents in toxicological research.

OECD Test Guideline Protocols Commonly Performed

MB Research Labs offers the following Toxicology Protocols, based on OECD Test Guidelines:

Toxicology Testing SpecialistsIn Vivo Studies

  • TG 401 Acute Oral Toxicity
  • TG 402 Acute Dermal Toxicity
  • TG 403 Acute Inhalation Toxicity
  • TG 404 Acute Dermal Irritation/Corrosion
  • TG 405 Acute Eye Irritation/Corrosion
  • TG 406 Skin Sensitization
  • TG 407 Repeated Dose 28-day Oral Toxicity Study in Rodents
  • TG 408 Repeated Dose 90-Day Oral Toxicity Study in Rodents
  • TG 410 Repeated Dose Dermal Toxicity: 21/28-day Study
  • TG 412 Subacute Inhalation Toxicity: 28-Day Study
  • TG 420 Acute Oral Toxicity – Fixed Dose Procedure
  • TG 423 Acute Oral toxicity – Acute Toxic Class Method
  • TG 425 Acute Oral Toxicity: Up-and-Down Procedure
  • TG 429 Skin Sensitization - Local Lymph Node Assay (LLNA)
  • TG 436 Acute Inhalation Toxicity – Acute Toxic Class Method
  • TG 442B Skin Sensitization - BrdU ELISA Method

We Have the Experience. Over 45 Years of Toxicology Testing Excellence.

Since 1972, MB Research Laboratories, a GLP contract research laboratory, has been conducting acute, subchronic / chronic toxicological and pharmacological studies.

  • MB Research provides industry-leading general toxicology services for the pharmaceutical, biotechnology, medical device and agrochemical industries and government agencies.
  • Routine and non-traditional toxicology studies are performed, custom testing services to meet specific testing needs is available.
  • Study Directors and technicians strive to consistently deliver exemplary results to support both Good Laboratory Practices(GLP) and non-GLP studies.

With a wide range of in vivo and in vitro testing test protocols available, MB Research Labs offers comprehensive capabilities to address your unique needs and goals.

Complete support services including consultation, protocol development, quality assurance, analytical chemistry and archive facilities are integral components of studies performed at MB.  Our technical and support procedures are in full compliance with OECD, FDA, and EPA.


MB's Institutional Animal Care and Use Committee (IACUC) meets at least six times each year to monitor the care and use of research animals. The committee reviews procedures, protocols and the facility to ensure that all phases meet or exceed the requirements of the Animal Welfare Act and the Guide for the Care and Use of Laboratory Animals.

MB Research Laboratories prides itself on pursuing alternative toxicological methods that reduce, refine and replace the use of animals in toxicological research. For over 25 years, MB has pioneered the development and validation of alternative tests with a goal on replacing laboratory animals in toxicological research.