Skin irritation tests are performed using in vitro 3D human skin tissue models. in vitro 3D human skin tissue models
closely mimic the human epidermis that were developed to create an in vitro (non-animal) alternative to the animal-based Draize Skin
Irritation Test utilized by the cosmetics, personal care, household products, chemical, pharmaceutical, and biotech industries.
MB Research offers skin irritation test models that have been endorsed by the ECVAM Scientific Advisory Committee (ESAC) as validated
in vitro replacement for the Draize Skin Irritation Test - OECD Test guidelines 439.
When assessing skin irritation, dermal sensitization may also be a concern. MB Research has developed a non-animal Integrated Testing
Strategy (ITS) for chemical-induced contact hypersensitivity (skin sensitization). This ITS provides a completely non-animal
alternative to traditional testing methods. Together, our three assays address three key events on the skin
sensitization adverse outcome pathway (AOP).
MB Research Labs works closely with other leaders in the field of in vitro toxicology and is dedicated to advancing techniques that reduce the use of
live animals in Toxicological Research. Below are several related sources that are helpful in developing and validating novel in vitro toxicology testing methods.