QVC Testing

Toxicological Safety Testing

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MB Research Labs conducts Toxicological Risk Assessment Tests often required for QVC Dossier Review. MB performs in vitro (non-animal) product safety testing using cells, tissue constructs and excised tissues that reduce the use and need for live laboratory animal testing.
45yrs Experience in Toxicology Testing

Your Trusted In Vitro Toxicity Testing Partner.

Call for Quote or for more information about your in vitro toxicity testing needs:US 1-215-536-4110 Or Contact MB.

We Have the Experience. Over 45 Years of Toxicology Testing Excellence.

MB Research has been protecting people since 1972. We are contract research laboratory specializing in consumer product, chemical and cosmetic safety testing.

  • MB Research Labs provides industry-leading general toxicology services commonly asked for your type of product.
  • Routine and non-traditional toxicology studies are performed daily.
  • We also have custom testing services to where we can design specific testing protocols to meet your needs.

MB Research offers wide range of in vitro test protocols available that can be asked for to complete your QVC Dossier - In Vitro Testing

Complete support services including consultation, protocol development, quality assurance, analytical chemistry and archive facilities are integral components of studies performed at MB.  Our technical and support procedures are in full compliance with OECD, FDA, and EPA.

3D Tissue Technology


Typical Endpoints

  • Cytotoxicity - MTT
  • Cytokine Production
  • Histology

Available Tissue Models

  • Skin/Dermal
  • Eye/Ocular
  • Inhalation - Airway
  • Intestinal
  • Oral/Buccal & Gingival
  • Melanocyte co-cultured
  • Hepatocyte spheroids
  • Other models are available
MB Research Labs conducts Good Laboratory Practice (GLP) compliant in vitro toxicology assays as well as low-cost screening studies for clients in the cosmetic, consumer product, chemical, biotech and pharmaceutical industries.

NEW - OptiSafe™ Non-Animal Ocular Irritation Test

  • OptiSafe™
  • An in vitro test method in which a test substance is applied to a semi-permeable membrane. Damage to macromolecules in the membrane is measured to assess the test substance‚Äôs potential to cause eye irritation.
  • Can be used to determine the irritation potential of cosmetics, creams, and a wide variety of consumer products. Results are presented as GHS, EPA classifications, an ocular irritation score and class.

Three Dimensional(3D)Human Ocular Tissue Equivalent Systems

  • MatTek EpiOcular™, SkinEthic corneocyte models
  • These models mimic characteristics of the epithelium of the eye
  • Unique properties of 3D models allow test articles to be applied topically, allowing testing of solids, organics, and insoluble materials

Bovine Corneal Opacity and Permeability Assay (BCOP)

  • Draize Rabbit Eye Test Alternative
  • Uses excised bovine corneas normally discarded
  • Measures two endpoints; 1) Changes in opacity, reflecting protein denaturation and corneal injury, and 2) Fluorescent dye permeability reflecting damage to corneal epithelium
  • Optional histological endpoint is available (H & E staining)
  • Measurement of pro-inflammatory mediators in liberated corneal cells (by flow cytometry or ELISA)

Hen's Egg Test-Chorioallantoic Membrane (HET-CAM)

  • Draize Rabbit Eye Test Alternative
  • Uses fertilized chicken eggs on embryonic day 10 or 14 of development
  • Measures hemodynamic effects, injury, and anti-angiogenic effects to the membrane microvasculature
  • Especially useful for alcohol-containing formulations

Chorioallantoic Membrane Vascular Assay (CAMVA)

  • Uses fertilized chicken eggs on embryonic day 10 or 14 of development
  • Measures hemodynamic effects, injury, and anti-angiogenic effects to the membrane microvasculature
  • Especially useful for alcohol-containing formulations

Porcine Cornea Reversibility Assay (PorCORA)

  • Draize Ocular Irritation Alternative
  • Measures recovery of corneal epitheilum after topical dosing to discriminate between severe irritation or ocular corrosivity