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MB Research co-authored/presented the following posters at the 2010 Society of Toxicology Annual Meeting in Salt Lake City, Utah. To view and print our posters, please click on the links below.
Porcine Corneal Ocular Reversibility Assay (PorCORA) Predicts EU R41 and GHS Category 1
- A 32-reference compound validation of the PorCORA testing method which yielded very favorable results correctly predicting Reversibility (88%), EU:R41 (91%), GHS: Category 1 (91%), and EPA: Category I (88%).
MB Research co-authored/presented the following posters at the 2009 Society of Toxicology Annual Meeting in Seattle. To view and print our posters, please click on the links below.
A 3D skin model for cosmetic, chemical and medical device phototoxicity testing.
-Further validation of the Enhance Phototoxicity screening Assay in Reconstituted Skin (EPARS), a highly predictive phototoxicity assay, with endpoints of inflammatory mediator and gene expression that allow for investigation into the mechanisms of photosensitivity in a wide variety of consumer products.
Assessment Of Ultraviolet Light- And Chemical-Induced UDS In Various Cell Lines Using Flow Cytometry.
-FLow cytometry-based Unscheduled DNA Synthesis (FLUDS) screening and validation studies using chemicals and UV radiation.
Alternative Porcine Corneal Ocular Reversibility Assay Correlates with Draize Reversibility Data.
- An alternative ocular irritation assay to the Draize Rabbit Eye test that can determine reversibility without the use of live animals.
PorFocal, for your eyes only!
- An alternative ocular irritation assay that is capable of determining ultra-low level irritation is excised porcine corneas but also makes it possible for long-term and/or multiple topical application of test substances.
MB Research co-authored/presented the following posters at the 2009 American College of Toxicology Annual Meeting.
Chorioallantoic Membrane Vascular Assay (CAMVA) and Bovine Corneal Opacity and Permeability Assay (BCOP) Historical Data on Personal Care Products Over Fourteen Years.
- A review of historical data collected on personal care products over the course of 14 yrs in order to develop custom product testing strategy.
Ocular Damage Reversibility of Three Commercially Available Personal Care Products Using the PorCORA.
- Ocular Irritation and Reversibility Testing using personal care products.
MB Research presented the following posters at the 2008 Society of Toxicology Annual Meeting in Seattle. To view and print our posters, please click on the links below.
"The Porcine Corneal Opacity and Reversibility Assay is an alternative assay that provides evidence of reversible eye irritancy."(PORCORA_SOT_2008.pdf)
- an ex vivo alternative assay that can assess both potential eye irritation and reversibility using excised porcine corneas. There has been favorable correlation between recovery in the in vivo Draize rabbit eye irritation results and the PorCORA.
"Confocal Microscopy of Reversibility in Excised Porcine Corneas." (Confocal_SOT_2008.pdf)
- The PorCORA measures corneal damage and recovery for extended time periods using excised porcine corneas. Tissue damage is assessed by fluorescein retention in the corneas over time and cell viability is measured by confocal microscopy.
"Development of an Oral Photo-LLNA to Identify Photoallergens ." (Oral_Photo-LLNA_SOT_2008.pdf)
- A cytometry-based local lymph node assay (LLNA) adapted to determine the photoallergenic potential of orally administered compounds in the quinolone and quinaxalin antibiotic groups.
MB Research presented the following posters at the 2007 Society of Toxicology Annual Meeting in Charolette.
"Comparison of in vitro phototoxicity Test Methods: 3T3 NRU PT vs. Enhanced Phototoxicity screening Assay in Reconstituted Skin (EPARS)." (3T3vsEPARS_SOT_2007.pdf)
- A side-by-side comparison between 3T3 Neutral Red Uptake Phototoxicity Test and an in vitro phototoxicity test based on three-dimensional, differentiated human keratinocyte cultures, which can accommodate a wide range of vehicles and allow direct topical application of test substances - the "Enhanced Phototoxicity Assay in Reconstituted Skin (EPARS)".
"Use of An Enhanced Local Lymph Node Assay To Correctly Classify Irritants and False Positive Substances.." (ELLNA_SOT_2007.pdf)
- A major weakness of the local lymph node assay is that irritants can produce increases in stimulation index (SI >3) in manner analogous to true sensitizers or allergens. Herein we use an enhanced LLNA with immunophenotypic endpoints and ear thickness measurements to characterize, identify, and correctly classify additional irritants to distinguish true sensitizers.