MB Research Laboratories - Porcine Cornea Opacity and Reversibility Assay

Jobs at MB

MB Research Labs
PO Box 178 Spinnerstown, PA 18968
voice: (215) 536-4110
fax: (215) 536-1816

Alternative Assay Differentiates EU R36/R41, GHS Category I/II and EPA Category I/II

Reduces the Need for Rabbit Testing.

Recently, we developed the Porcine Corneal Opacity Reversibility Assay (PorCORA) assay, an alternative ocular irritation reversibility assay.
In a 32 compound validation, PorCORA correctly predicted ocular reversibility (88%), EU: R41 (91%), GHS: Category 1 (91%), and EPA: Category I (88%).
PorCORA measures corneal damage and recovery over a 21-day testing period using porcine corneas excised from waste abattoir eyes.
PorCORA is the only non-animal test system able to predict ocular hazard classifications and is currently undergoing regulatory consideration.
MB Research has been conducting in vivo ocular toxicology testing since 1972 and has conducted over 9,700 rabbit eye studies.
We have pioneered ocular alternatives such as the Chorioallantoic Membrane Vascular Assay (CAMVA) and the Bovine Corneal Opacity & Permeability (BCOP) Assay and have conducted 5,600 BCOPs since 1989.

Home | About MB | Services | 3 R's Info | LLNA | Search Alternatives | FAQ
Accreditations | MB News | Contact Us | Posters | Jobs at MB | Links Page

Copyright © 2000 - 2009, MB Research Laboratories.

Assay Development Update

Alternative Assay Differentiates EU R36/R41, GHS Category I/II and EPA Category I/II

Reduces the Need for Rabbit Testing.