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The phototoxic potential of pharmaceutical, chemical, cosmetic and consumer products is a growing concern as the environment changes and the increased risk of sundamaged skin heightens.
Phototoxic drugs includes several common antibiotics such as tetracyclines, quinolones, and sulfonamides; tranquilizers; nonsteroidal anti- inflammatory drugs (NSAIDs); diuretics; oral diabetes medication; and cancer drugs.
Some suncreens and fragrances have also been known to have photoallergic reactions, such as Salicylates, Para-aminobenzoic acid (PABA), Musk ambrette and 6-Methylcoumarin.
MB Research Labs has developed in vitro and in vivo photobiology assays to address this growing need as well as advance the use of alternative toxicology methods.
MB Research Labs has developed and has performed validation studies of a GLP 3T3 Neutral Red Uptake Photoxicity Assay - an in vitro phototoxicity screening test.
EPARS - Enhanced Phototoxicity screening Assay in Reconstituted Skin
Currently, MB Research scientists are conducting validation studies of phototoxicity assay that utilizing three dimensional human tissue constructs.
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