OECD Guidelines for the Testing of Chemicals

Regulatory Toxicology Testing

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OECD Guidelines for the Testing of Chemicals


The OECD Guidelines for the Testing of Chemicals is an internationally agreed upon collection of testing methods used by government, industry and independent laboratories to identify and characterize potential chemical hazards. These approved assays are testing tools used primarily in regulatory safety testing as well as, subsequent chemical product notifications, chemical registrations and in chemical evaluations. They can also be used for the selection and ranking during the development of new products and chemical agents in toxicological research.

OECD Test Guideline Protocols Commonly Performed

MB Research Labs offers the following Toxicology Protocols, based on OECD Test Guidelines:

Toxicology Testing SpecialistsIn Vivo Studies

  • TG 401 Acute Oral Toxicity
  • TG 402 Acute Dermal Toxicity
  • TG 403 Acute Inhalation Toxicity
  • TG 404 Acute Dermal Irritation/Corrosion
  • TG 405 Acute Eye Irritation/Corrosion
  • TG 406 Skin Sensitization
  • TG 407 Repeated Dose 28-day Oral Toxicity Study in Rodents
  • TG 408 Repeated Dose 90-Day Oral Toxicity Study in Rodents
  • TG 410 Repeated Dose Dermal Toxicity: 21/28-day Study
  • TG 412 Subacute Inhalation Toxicity: 28-Day Study
  • TG 420 Acute Oral Toxicity – Fixed Dose Procedure
  • TG 423 Acute Oral toxicity – Acute Toxic Class Method
  • TG 425 Acute Oral Toxicity: Up-and-Down Procedure
  • TG 429 Skin Sensitization - Local Lymph Node Assay (LLNA)
  • TG 436 Acute Inhalation Toxicity – Acute Toxic Class Method
  • TG 442B Skin Sensitization - BrdU ELISA Method

Toxicology Testing SpecialistsIn Vitro Studies

  • TG 431 In Vitro Skin Corrosion: Reconstructed Human Epidermis (RHE) Test Method
  • TG 432 In Vitro 3T3 NRU Phototoxicity Test
  • TG 437 Bovine Corneal Opacity and Permeability (BCOP) Test Method
  • TG 439 In Vitro Skin Irritation: Reconstructed Human Epidermis Test Method
  • TG 442C In Chemico Skin Sensitization - Direct Peptide Reactivity Activation Assay (DPRA)
  • TG 442D In Vitro Skin Sensitization - ARE-Nrf2 Luciferase Keratinocyte Activation
  • TG 471 Bacterial Reverse Mutation Test - Ames Test
  • TG 492 Reconstructed human Cornea-like Epithelium (RhCE) test method - 3D Tissue, MTT Assay

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MB's Institutional Animal Care and Use Committee (IACUC) meets at least six times each year to monitor the care and use of research animals. The committee reviews procedures, protocols and the facility to ensure that all phases meet or exceed the requirements of the Animal Welfare Act and the Guide for the Care and Use of Laboratory Animals.

MB Research Laboratories prides itself on pursuing alternative toxicological methods that reduce, refine and replace the use of animals in toxicological research. For over 25 years, MB has pioneered the development and validation of alternative tests with a goal on replacing laboratory animals in toxicological research.