MB Research Laboratories - In Vitro Toxicology

In Vitro Toxicology Assays

MatTek EpiDerm^TM - 3-Dimensional Human Keratinoctye Tissue Construct

MatTek EpiDerm^TM is an in vitro human tissue model, which is constructed of normal, human-derived epidermal keratinocytes (NHEK) which have been cultured to form a multilayered, highly differentiated model that closely parallels human skin.

EpiDerm^TM is organized into basal, spinous, and granular layers along a multi-layered stratum corneum with an air-liquid interface. This tissues also exhibit in vivo-like morphological and growth characteristics that allow topical application to the surface of the tissue which mimics the route of human exposure. Method endpoint is the
MTT ET-50 Tissue Viability Assay.

EpiDerm^TM has been successfully utilized in alternative in vitro toxicology tests for dermal corrosivity, skin irritation, and phototoxicity.

Applications: product development/efficacy, claims substantiation, safety assessment, and target organ research applications.

MB Research Labs is a MatTek-approved contract testing laboratory for EpiDerm^TM and EpiOcular^TM product evaluations. EpiDerm and EpiOcular are trademarks of MatTek Corporation.