Enhanced Phototoxicity screening Assay in Reconstituted Skin (EPARS)

MB Research Laboratories has developed and prevalidated an in vitro screening test for phototoxicity, EPARS, to replace current standard phototoxicity tests, like the ICCVAM accepted 3T3 Neutral Red Uptake Phototoxicity Test (3T3 NRU PT).

The phototoxic potential of chemicals, cosmetics, dietary supplements and pharmaceuticals are a major and growing concern with the diminishing protective o-zone layer and increasing cases of sundamaged skin.

Although the 3T3 NRU PT has been accepted by ICCVAM, EPARS is significantly superior to the 3T3 NRU PT viability test because it overcomes several limitations of the accepted test.

Posters/Presentations

"EPARS: An In Vitro Phototoxicity Test Using Epidermal Tissue Models"   - 2216KB
- An improvement on existing photo-cytotoxicity tests by (1) accommodating the topical application of test articles and (2) using a primary human cell-based tissue with a morphology that approximates the 3-dimensional characteristics of human skin.

Society of In Vitro Biology 2006 Abstract.

 

The project described above is currently being supported by grant number R44-ES-11927-02 from the National Institute of Environmental Health Sciences (NIEHS), NIH. Its contents are solely the responsibility of the authors and do not necessarily represent the official view of the NIEHS, NIH.

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