EPA Regulatory Guidelines - OCSPP Series 870

In Vivo & In Vitro Toxicology Testing

Contact for Quotation Now

OCSPP.COM

MB specializes in the conduct of Good Laboratory Practice (GLP) compliant toxicology assays. MB Research studies are designed to meet the requirements of the applicable regulatory agencies, or tailored to meet your specific needs.

MB Research offers more than 40 years experience in the conduct of acute, sub-chronic and chronic toxicology the following studies designed to meet the Office of Chemical Safety and Pollution Prevention (OCSPP) regulatory guidelines.

OCSPP Series 870 (OCSPP Harmonized Guidelines)*

*Formerly known as OPPTS.

Acute Toxicity Guidelines

(Background)
  • 870.1100 - Acute Oral Toxicity **
  • 870.1200 - Acute Dermal Toxicity **
  • 870.1300 - Acute Inhalation Toxicity **
  • 870.2400 - Primary Eye Irritation**
  • 870.2500 - Primary Dermal Irritation**
  • 870.2600 - Skin Sensitization Test - Buehler Method & LLNA (OECD 429) **

** Link to pdf

Subchronic Toxicity Guidelines

  • 870.3050 - Repeat Dose 28-Day Oral Toxicity Study **
  • 870.3100 - 90-Day Oral Toxicity **
  • 870.3250 - 90-Day Dermal Toxicity **

** Link to pdf

Genetic Toxicity Guidelines

  • 870.5100 - Bacterial Reverse Mutation Test (Ames) **

Other In Vivo Capabilities

  • Pharmacology
  • In Vivo Efficacy
  • Toxicokinetics / Pharmacokinetics
  • Neurotoxicity Screen Studies (Functional Observational Battery)
  • Mouse Ear Swelling Test
  • Oral Mucosal Irritation (Hamster, Rat)
  • Oral Tissue Corrosivity (Rat)
  • Vaginal & Anal Mucous Membrane Irritation (Rabbit)
  • Medical Device Testing – Subcutaneous Implant
  • Intra-vaginal Irritation (Rabbit)
  • Penile Irritation (Rabbit)
  • Comedogenicity Assay (Rabbit)
  • Photo-Sensitization (Rabbit, Mouse – Photo-LLNA)
  • Photo-Toxic Irritation (Rabbit, Mouse)