Chorioallantoic Membrane Vascular Assay (CAMVA)

Assay Highlights:

 

Non-animal alternative to Draize Rabbit Eye test Uses the vascularized chorioallantoic membrane of fertile chicken eggs High concordance to in vivo data Topical Dosing: Liquids and Solids

Overview:

Damage to the vascular structure (i.e. ghost vessels, capillary injection, and/or hemorrhaging) of the chorioallantoic membrane (CAM) of fertilized chicken eggs is assessed after topical exposure of a test chemical which is then used as an endpoint to determine the potential for conjunctival irritancy.

Applications:

CAMVA can be used to investigate the vascular effects such as neovascularization, angiogenesis, and anti-angiogenesis, which are of particular interest to pharmaceutical and cosmetic product research and development.