Nov 17-18, 2003 - Immune-mediated Drug Hypersensitivity Reasctions (IDHR) Workshop, Mechanisms to Increase IDHR Research Opportunities, International Life Science Institute-Health and Environmental Sciences Institute (ILSI-HESI), Washington D.C.
Nov 2 - 5, 2003 - MB Representatives traveled to Washington D.C., to attend the 2003 Annual Meeting of the American College of Toxicology. Research Associates presented "Non-Radiometric Local Lymph Node Assay with Flow Cytometric Immunophenotype Analysis.", "Alternative Phototoxicity Test using 3D Epidermal Tissue Models.", and "In Ovo Carcinogenicity Assay: An Alternative to the Rodent Bioassay." during scientific poster sessions throughout the meeting.
Oct 27-28, 2003 - MB Research participated in the EPA FIFRA Scientific Advisory Panel advising of the adoption of Performance Standards developed by ICCVAM as a means of communicating the basis by which Corrositex, EPISKIN/EpiDerm and the Transcutaneous Electrical Resistance (TER) Assays are deemed acceptable for providing dermal corrosivity data.
Oct 5-8, 2003 - MB Research Officers attended the 54th Annual Toxicology Roundtable in Cape May, NJ. MB presented a talk on the application of the Local Lymph Node Assay to testing for photosensitization, "Photo-LLNA".
Jun 7-13, 2003 - Los Alamos Flow Cytometry Course, Los Alamos, NM.
Jun 2 - 4, 2003 - MB Representatives attended the annual SBIR National Conference in Washington, D.C.
May 31 - Jun 5, 2003 - MB Research recently attended the 2003 Congress on In Vitro Biology Annual Meeting. MB presented the following posters: "The EpiOcular Prediction Model: In Vivo versus In Vitro Draize Score for Consumer Products" and "Enhanced Phototoxicity Assay Using Reconstitute Skin".
May 30, 2003 - MB Research Associates complete the Final Progress Report for SBIR Grant R43-ES109227-01, "Enhanced Phototoxicity Assay in Reconstituted Skin (EPARS)". EPARS is an innovative in vitro alternative assay designed to replace animal phototoxicity testing. Further development is planned and a Phase II SBIR application is expected to be submitted to the National Institutes of Health.
March 13- 16, 2003 - MB Representatives attended the 42nd Annual Society of Toxicology Meeting in Salt Lake City, Utah. MB presented the "Enhanced Local Lymph Node Assay Using Flow Cytometry" and "The In Ovo Carcinogenicity Assay".
November 2002: 23rd Annual American College of Toxicology, MB Research presented "Neurotoxicity and Functional Defects in Rodents Induced by Oral Administration of Tea Tree Oil", "Photo-LLNA: A Non-Radioactive, Flow Cytometry-based Local Lymph Node Assay with Multiple Endpoints to Identify Photosensitizers and Irritants", "Characterization of the Sensitizing Potential of a Strong Dermal Irritant Using an Enhanced Local Lymph Node Assay", and "An Alternative Test for Photoirritants: The In Ovo Phototoxicity Assay (IOPA)".
August 2002: MB Research receives notification that SBIR Grant "Enhanced Phototoxicity Assay in Reconstituted Skin (EPARS)" has been approved for funding for the development. EPARS is a high-throughput in vitro screening test to detect the phototoxic potential of chemicals, cosmetics, dietary supplements and pharmaceuticals.
August 2002: MB Research attended the 4th World Congress on Alternatives and Animal Use in Life Sciences in New Orleans, and presented "PHOTO-LLNA: A Non-Radioactive, Flow Cytometry-based Local Lymph Node Assay with Multiple Endpoints to Identify Photosensitizers, Sensitizers and Irritants", "An Alternative Test for Photoirritants: The In Ovo Phototoxicity Assay" and "Characterization of the Sensitizing Potential of a Strong Dermal Irritant Using An Enhanced Local Lymph Node Assay".
March 2002: Society of Toxicology in Nashville, TN. MB Research scientists presented "Development of an Alternative Test for Photoirritants: The In Ovo Phototoxicity Assay", "Characterization of the Sensitizing Potential of a Strong Dermal Irritant Using An Enhanced Local Lymph Node Assay", "Human Prostate Cancer Cells Treated with Saw Palmetto Extracts Selectively Accumulate a Brown Pigmented Material: Correlation with Altered Cellular Proliferation and Morphology", and "Tea Tree Oil Administered Orally Induces Specific Neurotoxicity in Rats."
December 10 - 12, 2001: MB Research Director of Toxicology serves as panelist on Environmental Protection Agency Scientific Advisory Panel (EPA SAP) for validation of the Local Lymph Node Assay (LLNA) as the preferred method for sensitization and review of the Up and Down Procedure.
November 4 - 7, 2001: 22nd Annual American College of Toxicology, Washington D.C. - MB presented posters entitled "Alternative Phototoxicity Assay Using Chorioallantoic Membrane of the Chicken Egg (Photo-CAM)", "Selective Effects of Saw Palmetto Extracts on the Proliferation of Human Cancer Cells ", and "Insulin Modulates Cytokine-stimulated Nitric Oxide (NO)".
November 2001: SBIR grant application Alternative Photosensitization Assay in the Mouse (Photo-LLNA) was funded with an award of $100,000.
October 14 - 17, 2001: Toxicology Roundtable Presentation: "The Incredible Experimental Egg".
May 21, 2001: Phototoxicity Using The Chorioallantoic Membrane (PhotoCam) was funded with an award of $100,000.
April 1, 2001: An SBIR grant application was submitted for Enhanced Cytometry-based Immunotoxicity Assay (PFC).
March 25 - 29, 2001: MB presented poster #1735 - Insulin Potentiates the Production of Nitric Oxide (NO) by Interferon in Murine Keratinocytes at the Society of Toxicology (SOT) meeting in San Francisco, CA.
December 1, 2000: MB submitted an SBIR grant application for Alternative Photosensitization Assay in the Mouse (Photo-LLNA).
September 15, 2000: In Ovo Carcinogenicity Assay (IOCA) was funded with an award of $100,000.
September 1, 2000: Development Of A Human Somatic Gene Mutagenicity Assay (GPA) was funded with an award of $100,000
June 15, 2000: MB Research has received notice from the NIH that our SBIR project, In Ovo Carcinogenicity Assay (IOCA) will be funded by the NIEHS ($100,000) by October, 2000.
May 15, 2000: Enhanced Local Lymph Node Assay Using Flow Cytometry (LLNA) was funded with an award of $100,000.
May 1, 2000: MB has completed the first half of its Phase 1 SBIR project, the Enhanced Local Lymph Node Assay Using Flow Cytometry (LLNA). Early findings show that strains of mice other than CBA/J are useful in this assay, and that the B:T cell ratio in the node is a useful predictive parameter.
April 1, 2000: MB Research has submitted three additional SBIR grant applications to the NIH. The titles for these are:
- Accelerated Bioassay for Carcinogenicity in Rodents (ABC)
- Non-Radioactive, High-Throughput Endocrine Disruptor Binding (ED-BIND) Assay (was High Throughput Screen For Endocrine Disruptors)
- Flow (cytometry)-based Unscheduled DNA Synthesis (FLUDS) Assay
March 19 - 23, 2000: MB presented three posters at the Society of Toxicology (SOT) meeting in Philadelphia, PA:
- The EpiOcular Tissue Model: In Vivo Versus In Vitro Draize Scores For Consumer Products
- Glycerol-Mediated Photoreduction Of Hexavalent Chromium
- Role Of Glutathione In Contact Sensitization: Application Of A Flow Cytometry-Based Local Lymph Node Assay
March 1, 2000: MB Research has experienced steady growth in the past three years. The personnel count has increased from 14 to 23 employees, and our collaborations with NY Medical College, West Virginia University, Rutgers University, and Enviro-Bio-Tech have brought additional capabilities and expertise to our growing company. In the calendar year 1999, MB's study volume has increased by 38%.
December 31, 1999: MB submitted five SBIR grants over the past year. The titles for those are:
- Phototoxicity Using The Chorioallantoic Membrane (PhotoCam)
- Enhanced Local Lymph Node Assay Using Flow Cytometry
- In Ovo Carcinogenicity Assay (IOCA)
- High Throughput Screen For Endocrine Disruptors
- Development Of A Human Somatic Gene Mutagenicity Assay (GPA)
December 15, 1999: The National Institute of Health - NIEHS has funded a Phase I SBIR grant ($100,000) for further enhancement of the LLNA entitled Enhanced Local Lymph Node Assay Using Flow Cytometry (LLNA). This grant was submitted in April, 1999, a few months after MB Research began offering the standard LLNA Assay to its clients. For more information about the enhanced LLNA, please call 215-536-4110.
September 12, 1999: MB Research is pleased to announce the appointment of Dr. Edward Yurkow as Director of Research and study director for in vitro testing. Dr. Yurkow received his Ph.D. at Rutgers - UMDNJ and did post doctoral work at Massachusetts General Hospital (Harvard University). He has extensive experience in in vitro assays and flow cytometry. With the continuing increase in the number of in vitro studies requested, we plan to be prepared with well trained personnel to meet the needs of our sponsors.