In the early 90’s, in order to meet the growing need and demand for alternative testing methods to animal models, MB Research scientists began validation studies of alternative toxicology methods that could be cost effective for companies to utilize in their product stewardship programs, such as, the Chorioallantoic Membrane Vascular Assay (CAMVA) and the Bovine Corneal Opacity and Permeability Test (BCOP) - both Draize rabbit eye test alternatives.
In December 2006 , MB Research was awarded a Colgate-Palmolive Grant for Alternative Research to continue the development of PORCORA - Porcine Cornea Opacity/Reversibility Assay, another Draize ocular irritancy alternative test, which is being developed to quantify cornea epithelial damage after exposure to a chemical as well as determine reversibility of that damage.
MB Research also offers a validated a non-radioactive, Flow Cytometry-based Local Lymph Node Assay (FC-LLNA) which not only can determine the sensitization potential of a chemical, but can also distinguish between sensitizers and irritating sensitizers by examining additional immunphenotypic endpoints. Other verisons of this assay, such as photo-sensization screening tests are available.
MB Research has many years of experience in the use and development of in vitro toxicology assays. We have standard protocols for the assessment of ocualr and dermal irritation, cytotoxicity, immunotoxicity, and phototoxicity.
MB Research Labs has a well-equipped laboratory dedicated to the use and development of in vitro toxicology assays.
MB Research Study Directors monitor all aspects of the conduct of in vitro studies. Many of these assays are conducted under GLP regulations.
Cytotoxicity Agar Overlay - L929 cells
CAMVA - Draize Rabbit Eye Test Alternative Test Method