MB Research Laboratories - 3Rs - Refine, Reduce, Replace

3 Rs: Reduce, Refine, and Replace

What are the 3 Rs?

The principle of the 3Rs was first mentioned by William Russell and Rex Burch in 1959. In their book "The Principles of Humane Experimental Technique", they classified humane techniques under the headings Refinement, Reduction, and Replacement, commonly known now as the 3Rs.

MB Research Laboratories prides itself on pursuing alternative toxicological methods that reduce, refine and replace the use of animals in laboratory research and has worked with many of the leaders in this field to advance the development and validation of alternative tests with a goal on replacing laboratory animals in toxicological research.

Currently, MB Research offers a wide variety of in vitro and alternative toxicity tests, such as the Local Lymph Node Assay (LLNA), the 3T3 Neutral Red Uptake Phototoxicity Assay (3T3 NRU Phototox), the Bovine Corneal Opacity and Permeability Assay (BCOP), the Chorioallantoic Membrane Vascular Assay (CAMVA), MatTek EpiDerm^TM, EpiOcular^TM and MelanoDerm^TM Assays.