MB Research Laboratories - In Vitro Toxicology using three dimensional tissue constructs

3-D Human Tissue Models

Three dimensional human tissue models have proven to be very effective screening tools for irritation and corrosivity testing.

These tissues have been useful in development of alternative, non-animal test methods. Tissue constructs have been utilized for many years for ocular and dermal toxicity screening at MB Research Labs for the cosmetic, petrochemical, and pharmaceutical industries.

Other tissue types (buccal, brochial, vaginal, dermal, ocular, tanned epidermis) that exhibit in vivo-like morphological and growth characteristics are available from various vendors. MB Research frequently works closely with manufacturers to develop testing protocols that fit our clients' needs.

More and more interest in the utility of these models has increased especially since their use reduces the number of animals used in Toxicology testing.

Currently, MB Research scientists are conducting validation studies of phototoxicity assay that utilize three dimensional human tissue constructs to address shortcomings for accepted 3T3 NRU Phototoxicity Test. For more information, please see:

EPARS - Enhanced Phototoxicity screening Assay in Reconstituted Skin