Toxicology Testing Services

Your Toxicologist. Your Trusted Testing Partner.

MB proudly serves these industries:

Compliant Regulatory  Toxicology Testing. us food and drug administration, environmental protection agency, oecd, ghs, aaalas Chemical Testing. Product Stewardship. Worker Safety. Cosmetics Testing. Alternatives to Animal Testing.

NEW - In Vitro Sensitization ITS

MB Research has developed a non-animal Integrated Testing Strategy (ITS) for chemical-induced contact hypersensitivity (skin sensitization). This ITS provides a completely non-animal alternative to traditional testing methods. Together, our three assays address three key events on the skin sensitization adverse outcome pathway (AOP).

Adverse Outcome Pathway (AOP)


The In Vitro Sensitization Assay (IVSA) is a keratinocyte activation test. IVSA uses an ELISA method to measure IL-18 release from a topically treated reconstructed 3D human keratinocyte tissue model.


The Human Cell Line Activation Test (h-CLAT) is a dendritic cell activation test. The h-CLAT uses flow cytometry to measure CD86 and CD54 expression on treated THP-1 cells in culture.


The Direct Peptide Reactivity Assay (DPRA) is an in chemico method used to predict epidermal protein binding. Binding of epidermal proteins is the molecular initiating event on the AOP. The DPRA uses HPLC to measure the depletion of synthetic peptides in solution following exposure to test chemicals.

Award Winning Research. Your Trusted Testing Partner.

MB Research Labs - Cosmetics, Chemicals, Consumer Products, Pharmaceuticals

Call for Quote or for more information about your testing needs:
US 1-215-536-4110

Or Contact MB.


What are TOXNotes?

TOXNotes are technical papers written by our team of Toxicologists on assays, procedures and strategies developed at MB Research Labs. TOXNotes highlight innovations in Alternatives to Animal Testing, and Novel advancements in Toxicological techniques.

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